Superiority vs. equivalence/non-inferiority: study design and meeting abstracts

Methodology of superiority vs. equivalence trials and non-inferiority trials.

The randomized clinical trial (RCT) is generally accepted as the best method of comparing effects of therapies. Most often the aim of an RCT is to show that a new therapy is superior to an established therapy or placebo, i.e. they are planned and performed as superiority trials. Sometimes the aim of an RCT is just to show that a new therapy is not superior but equivalent to or not inferior to a...

Superiority, equivalence, and non-inferiority trials.

When the aim of the randomized controlled trial (RCT) is to show that one treatment is superior to another, a statistical test is employed and the trial (test) is called a superiority trial (test). Often a nonsignificant superiority test is wrongly interpreted as proof of no difference between the two treatments. Proving that two treatments are equal in performance is impossible with statistica...

AAPM Annual Meeting Abstracts

AAPM Annual Meeting Abstracts

Abstracts of Meeting

were equal and the time for 10 mis of saline to flow measured. These measurements were repeated after the intravenous injections of 2 mgs Glucagon or 30 mgs Probathine. Of the 29 patients with Glucagon, five patients had diameter increases of less than 5% these patients were treated with sphincterotomy or dilatation. Seven patients had unimpacted stones in the duct and as the model predicts the...

2010 Annual Meeting Abstracts